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Diversity-Oriented Synthesis of 13- to 18-Membered Macrolactams via Ring-Closing Metathesis

  作者 DANDAPANI SIVARAMAN; LOWE JASON T; COMER EAMON; MARCAURELLE LISA A  
  选自 期刊  Journal of Organic Chemistry;  卷期  2011年76-19;  页码  8042-8048  
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[摘要]An efficient build/couple/pair approach to diversity-oriented synthesis was employed to access several structurally complex macrolactams. In this paper, we describe the successful evaluation of ring-closing metathesis toward the systematic generation of skeletal diversity. By appropriately varying the nature and chain length of the alkenol fragment, a diverse collection of 13- to 18-membered macrolactams were obtained.

 
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