Enantioselective Friedel-Crafts Aminoalkylation Catalyzed by Chiral Ammonium 1,1 '-Binaphthyl-2,2 '-disulfonates

[摘要]：A catalytic enantioselective Friedel-Crafts aminoalkylation between aromatic aldimines and N-benzylpyrrole with the use of a homogeneous chiral ammonium salt, (R)-BINSA-N,N-dimethylbutylamine, as a dynamic Bronsted acid-Bronsted base catalyst, is reported. Unlike the results with conventional catalysts, remarkably high reactivity was established at -78 degrees C within 30 minutes, and the corresponding aryl(1H-pyrrol-2-yl) methanamines were obtained with good to high enantioselectivities.

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