An Approach to Lauroxanes by Iterative Use of Co-2(CO)(6)-Acetylenic Complexes. A Formal Synthesis of (+)-Laurencin

[摘要]：A new approach to lauroxanes by a powerful and highly convergent methodology based on iterative use of Co-2(CO)(6)-acetylenic complexes is described. The strategy employs an intermolecular Nicholas reaction to form unsaturated branched linear ethers, a ring closing metathesis to obtain the cobalt complex cyclic ethers, and an isomerization promoted by montmorillonite K-10. A short synthesis of cyclic ethers of seven-, eight-, and nine-membered rings is described. Additionally, the methodology is exemplified by the formal synthesis of (+)-laurencin, a red algae metabolite.

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