Synthesis of Medicinally Interesting Polyfluoro Ketones via Perfluoroalkyl Lithium Reagents.

[摘要]：The addn. of (pentafluoroethyl)- and (heptafluoropropyl)lithium to various acyl derivs. was studied. Weinreb and morpholine amides led to polyfluoro ketones in high to quant. yields in short reaction times. Derivs. of 2-fluorocarboxylic acids may produce 1,1,1,2,2,4-hexafluoro ketones and 1,1,1,2,2,3,3,5-octafluoro ketones. The methodol. can provide inhibitors for various lipolytic enzymes, including phospholipase A2.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内