New octahydropyrido[3,4-b]acridine scaffolds for combinatorial chemistry.

[摘要]：Friedlaender reaction of aminobromobenzaldehydes with an optically active decahydroisoquinolone building block gave new octahydropyrido[3,4-b]acridines I and II with quant. regioselectivity. The products define a platform for combinatorial chem. Bromine functions could be reacted further using Suzuki, Heck, Sonogashira, and Buchwald-Hartwig cross-coupling reactions as well as cyanations. The secondary amino function was deprotected and coupled with amino acids and benzoic acid derivs.

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