Evaluation of Di-Sansalvamide A Derivatives: Synthesis, Structure-Activity Relationship, and Mechanism of Action

[摘要]：Described is the SAR of 18 di-sansalvamide A derivatives and the mechanism of action of the most potent compound. We show that this scaffold is a promising lead in the development of novel cancer therapeutics because it is cytotoxic at nanomolar potency, inhibits a well-established oncogenic target (Hsp90), and does not share structural motifs with current drugs on the market.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内