Synthesis and Antitumor Activity of Mechercharmycin A Analogues.

[摘要]：such as I (R = H; R1 = H, MeOCH2CH2OCH2CH2OCH2COOCH2; RR1 = CH2) are prepd. as antitumor agents and tested for their inhibition of human cancer cell lines. Of the compds. tested, I (R = H; R1 = H, MeOCH2CH2OCH2CH2OCH2COOCH2; RR1 = CH2) inhibit the growth of human colon, lung, and breast cancer cell lines most effectively; the compds. also alter cell cycle progression and induce apoptosis in the human colon, breast, and lung cancer cell lines.

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