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Discovery of Potent and Selective Small-Molecule PAR-2 Agonists.

  作者 Seitzberg, Jimmi Gerner;Knapp, Anne Eeg;Lund, Birgitte Winther;Mandrup Bertozzi, Sine;Currier, Erika A.;Ma, Jian-Nong;Sherbukhin, Vladimir;Burstein, Ethan S.;Olsson, Roger;  
  选自 期刊  Journal of Medicinal Chemistry;  卷期  2008年51-18;  页码  5490-5493  
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[摘要]conditions with a strong inflammatory component. We present the discovery and characterization of two structurally different, potent, selective, and metabolically stable small-mol. PAR-2 agonists. These ligands may be useful as pharmacol. tools for elucidating the complex physiol. role of the PAR-2 receptors as well as for the development of PAR-2 antagonists.

 
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