Heterotrimeric Coiled Coils with Core Residue Urea Side Chains.

[摘要]：The authors report several coiled coil heterotrimers with varying core residue buried polar groups, all with Tm values > 43? Introduction of new synthetic side chain structures, including some terminating in monosubstituted ureas, diversifies the pool of viable core residue candidates. A study of core charge pairings demonstrates that, unlike dimeric systems, trimeric coiled coils do not tolerate guanidine-guanidine contacts, even in the presence of a compensating carboxylate. Overall, the roster of feasible coiled coil designs is significantly expanded.

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