| |
[摘要]：Four hydroxylated pyrrolizidinones have been obtained from b-ketoesters derived from L-pyroglutamic acid or 4-(R)-hydroxy-L-pyroglutamic acid. The asym. hydrogenations, in the presence of BinapRuBr2 catalysts, of such b-ketoesters bearing pyrrolidinones proceeded with high diastereomeric excesses leading to a complete control of the abs. configuration at the C7 hydroxylated carbon atom of the azabicycles. |
|
