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[摘要]：The minimal fungicidal concentration (MFC) of dihydrosphingosine (DHS), phytosphingosine (PHS), and five short-chain DHS derivatives was determined for Candida albicans and Candida glabrata. In this respect, a C15-and a C17-homologue of DHS showed a 2- to 10-fold decreased MFC as compared to native DHS (i. e. C18-DHS). DHS derivatives that were active, that is, comprising 12, 15, 17, or 18 carbon atoms, induced accumulation of reactive oxygen species (ROS) in C. albicans. (C) 2008 Elsevier Ltd. All rights reserved. |
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