An Efficient Synthesis of Highly Functionalized 4H-Pyrano[3,2-d]isoxazoles via Isocyanide-Based Three-Component Reaction

[摘要]：We present a novel, convenient, and efficient method for synthesizing polysubstituted 4H-pyrano[3,2-d]isoxazoles based on a three-component reaction. The zwitterions generated from the reaction of isocyanides and dialkyl acetylenedicarboxylates are reacted with 3-phenylisoxazol-4-(5H)-one to produce the title compounds in good yield.

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