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[摘要]：Eight new benzotriazoloazepine derivatives have been synthesized starting from 7-methoxy-2,3,4,5-tetrahydro-1H-2-benzo[c]azepin-1-one. The compounds 2ac have been synthesized by the reaction of 7-methoxy-2,3,4,5-tetrahydro-1H-2-benzo[c]azepin-1-thione with various hydrazides. Reaction of 5 with hydrazine hydrate, followed by treatment of the resultant hydrazone with formic acid, gave corresponding 9-alkoxy-6,7-dihydro-5H-benzo[c][1,2,4]triazolo[4,3-a]azepine(6a,b). Cyclization of 5 with methyl carbazate gave 9-alkoxy-6,7-dihydro-2H-benzo[c][1,2,4]triazolo[4,3-a]azepin-3(5H)-one (7ac). The structures of the compounds were confirmed by their elemental analysis and spectral data. Their anticonvulsant activities have been initially screened. |
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