[摘要]：We examined the relationship between the structures of hetero-/homoleptic ruthenium(II) tris(bipyridine) metal complexes (Ru-II(bpy)(3)) and their binding properties for alpha-chymotrypsin (ChT) and cytochrome c (cyt c). Heteroleptic compound 1a binds to both ChT and cyt c in 1:1 ratio, whereas homoleptic 2 forms 1: 2 protein complex with ChT but 1:1 complex with cyt c. These results suggest that the structure of the recognition cavity in Ru-II(bpy)(3) can be designed for shape complementarity to the targeted proteins. In addition, Ru-II(bpy)(3) complexes were found to be potent inhibitors of cyt c reduction and to permeate A549 cells. (C) 2011 Elsevier Ltd. All rights reserved.
