Electrospinning Preparation and Drug-Delivery Properties of an Up-conversion Luminescent Porous NaYF(4):Yb(3+), Er(3+)@Silica Fiber Nanocomposite

[摘要]：Up-conversion (UC) luminescent porous silica fibers decorated with NaYF(4):Yb(3+), Er(3+) nanocrystals (NCs) (denoted as NaYF(4):Yb(3+), Er(3+)@silica fiber) are prepared by the electrospinning process using cationic surfactant P123 as a template. Monodisperse and hydrophobic oleic acid capped beta-NaYF(4): Yb(3+), Er(3+) NCs are prepared by thermal decomposition methodology. Then, these NCs are transferred into aqueous solution by employing cetyltrimethylammonium bromide (CTAB) as secondary surfactant. The water-dispersible beta-NaYF(4):Yb(3+), Er(3+) NCs are dispersed into precursor electrospinning solution containing P123 and tetraethyl orthosilicate (TEOS), followed by preparation of precursor fibers via electrospinning. Finally, porous alpha-NaYF(4):Yb(3+), Er(3+)@silica fiber nanocomposites are obtained after annealing the precursor fibers containing beta-NaYF(4):Yb(3+), Er(3+) at 550 degrees C. The as-prepared alpha-NaYF(4):Yb(3+), Er(3+)@silica fiber possesses porous structure and UC luminescence properties simultaneously. Furthermore, the obtained nanocomposites can be used as a drug delivery host carrier and drug storage/release properties are investigated, using ibuprofen (IBU) as a model drug. The results indicate that the IBU-loaded alpha-NaYF(4):Yb(3+), Er(3+)@silica fiber nanocomposites show UC emission of Er(3+) under 980 nm NIR laser excitation and a controlled release property for IBU. Meanwhile, the UC emission intensity of IBU-alpha-NaYF(4):Yb(3+), Er(3+)@silica fiber system varies with the released amount of IBU.

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