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Discovery of vinylcycloalkyl-substituted benzimidazole TRPM8 antagonists effective in the treatment of cold allodynia

作者	Calvo, RR; Meegalla, SK; Parks, DJ; Parsons, WH; Ballentine, SK; Lubin, ML; Schneider, C; Colburn, RW; Flores, CM; Player, MR

选自	期刊 Bioorganic & Medicinal Chemistry Letters; 卷期 2012年22-5; 页码 1903-1907

关联知识点

[摘要]：Thermosensitive transient receptor potential melastatin 8 (TRPM8) antagonists are considered to be potential therapeutic agents for the treatment of cold hypersensitivity. The discovery of a new class of TRPM8 antagonists that shows in vivo efficacy in the rat chronic constriction injury (CCI)-induced model of neuropathic pain is described. (c) 2012 Elsevier Ltd. All rights reserved.
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