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[摘要]：Two classes of dibutyltin(IV) hydroxamates complexes, formulated as the mononuclear mixed-ligand diorganotin(IV) complex [(n)Bu(2)Sn(HL)CI] a and the tetranuclear [(n)Bu(4)Sn(2)(HL)(2)(L)](2) b were fully characterized. X-ray diffraction analyses were also carried out for the representative complexes [(n)Bu(2)Sn(2,6-F(2)C(6)H(3)C(=O)NHO)C1](4a) and [[(n)Bu(4)Sn(2)(3-BrC(6)H(4)C(=O)NHO}(2){3-BrC(6)H(4)C(=NO)O)](2)](1b). The cytotoxicity of all compounds was tested by MTT and SRB assays against three human tumor cell lines HL-60, BGC-823 and KB. 1b and 4a have been shown to be more potent antitumor agents than other compounds and cisplatin. Annexin V FITC-PI assay was consistent with the MTT results. Cell cycle assay results indicated that KB cells displayed an arrest in the G(0)/G(1) phase and a decrease of S phase of the cell cycle at the low concentrations of 1b, 4a. (C) 2011 Elsevier Masson SAS. All rights reserved. |
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