Au-I Catalyzed Direct Hydroamination/Hydroarylation and Double Hydroamination of Terminal Alkynes

[摘要]：An efficient method for formal Markownikoff hydroamination/hydroarylation and double hydroamination of terminal alkynes has been developed. For example, treatment of terminal alkynes with amino-aromatics or diamines in the presence of 2-5 mol-% of Ph3PAuNTf2 in toluene at 100 degrees C gave the corresponding products in excellent yields. The method was shown to be applicable to a broad range of substrates and, more importantly, unlike our previously reported method, a tethered hydroxy group in the alkyne is not necessary. The mechanism of the reaction is also discussed.

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