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A Multicomponent Reaction between alpha-Substituted Acroleins, Nitroalkanes and Paraformaldehyde: Efficient Construction of Nitro delta-Lactol

  作者 XIONG GUOXI; WEI MOHUI; ZHOU YIRONG; LI YUNGUI; ZHANG FANGLIN; GONG YUEFA  
  选自 期刊  Synthesis;  卷期  2011年-21;  页码  3439-3446  
  关联知识点  
 

[摘要]A base-catalyzed multicomponent cascade reaction between alpha-substituted acroleins, nitroalkanes, and paraformaldehyde that proceeded smoothly to give high yields of functionalized delta-lactols under mild conditions, is described. This methodology is useful in the development of a concise synthetic route to natural products (+/-)-manzacidin A and C.

 
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