Modified Mukaiyama reaction for the synthesis of quinoline alkaloid analogues: Total synthesis of 3,3-diisopentenyl-N-methylquinoline-2,4-dione.

[摘要]：A general synthetic approach, capable of accessing a diverse range of 3,3-disubstituted quinoline-2,4-diones and 1,8-naphthyridine-2,4-diones via TiCl4-catalyzed C-acylation of silyl ketene acetals is described. The suggested methodol. platform is surveyed using different reaction conditions and is applied to the total syntheses of 3,3-diisopentenyl-N-methylquinoline-2,4-dione and 3-demethyl-N-methylatanine.

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