[摘要]：Serpin A1 (alpha 1-AT), the largest subgroup of serpins, presents in human plasma at high concentration and plays important regulatory roles in physiological and pathological processes. Accumulated evidence suggests that alpha 1-AT may play a role in controlling HIV-1 infection. In this study, we designed and synthesized a set of short linear peptides derived from the C-terminal sequence of alpha 1-AT. Since none of them showed significant anti-HIV-1activity, we proceeded to synthesize four short cyclic peptides having 7 amino acids, and we found that three of them exhibited significant anti-HIV-1 activity. One of these cyclic peptides, designated CPM, inhibited HIV-1 entry and infection at low mu M level, indicating that these short cyclic peptides could serve as leads for the development of novel anti-HIV-1 therapeutics. (C) 2012 Elsevier Ltd. All rights reserved.
