Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140
作者
MILLER CHRIS P; SHOMALI MAYSOUN; LYTTLE C RICHARD; ODEA LOUIS ST L; HERENDEEN HILLARY; GALLACHER KYLA; PAQUIN DOTTIE; COMPTON DENNIS R; SAHOO BISHWABHUSAN; KERRIGAN SEAN A; BURGE MATTHEW S; NICKELS MICTIAEL; GREEN JENNIFER L; KATZENELLENBOGEN JOHN A; TCHESNOKOV ALEXEI; HATTERSLEY GARY
[摘要]：This report describes the discovery of RAD140, a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM). The characterization of RAD140 in several preclinical models of anabolic androgen action is also described.
