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A Rapid Access to (+/-)-Sedamine and Some Original N-Benzyl Unsaturated Analogues

  作者 BOUSSONNIERE ANNE; RANAIVONDRAMBOLA TSIRESY; LEBRETON JACQUES; MATHEALLAINMAT MONIQUE  
  选自 期刊  Synthesis;  卷期  2010年-14;  页码  2456-2462  
  关联知识点  
 

[摘要]Reduction of N-alkyl-2-(2-hydroxy-2-phenylethyl) pyridinium salts using excess of sodium triacetoxyborohydride afforded exclusively the corresponding tetrahydropyridine derivative bearing a piperidine ring with a double bond in the 3,4-position. Furthermore, under these conditions, syn-1,3-amino alcohols were obtained in good yield and diastereoselectivity.

 
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