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[摘要]：This research program on the novel functions of Panax ginseng C. A. Meyer focused on the effects of ginseng rhizome on hair re-growth in androgenetic alopecia. Extracts of red ginseng rhizome showed greater dose-dependent inhibitory effects against testosterone 5 alpha-reductase (5 alpha R) when compared with extracts of the main root. Ginsenoside Ro, the predominant ginsenoside in the rhizome, and ginsenoside Rg(3), a unique ginsenoside in red ginseng, showed inhibitory activity against 5 alpha R with IC(50) values of 259.4 and 86.1 mu m, respectively. The rhizome of P. japonicus, which contains larger amounts of ginsenoside Ro, also inhibited 5 alpha R.Topical administration of extracts of red ginseng rhizomes ( 2 mg/mouse) and ginsenoside Ro ( 0.2 mg/mouse) to shaved skin inhibited hair re-growth suppression after shaving in the testosterone-treated C57BL/6 mice. These results suggest that red ginseng rhizomes containing both oleanane- and dammarane-type ginsenosides are a promising raw material for cosmetic use. This is the first report that ginsenoside Ro enhances in vivo hair re-growth based on their inhibitory activity against 5 alpha R in the androgenetic alopecia model. Copyright (C) 2011 John Wiley & Sons, Ltd. |
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