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Diamidinium and iminium aromatics as new aggregators of the bacterial signaling molecule, c-di-GMP

  作者 Kelsey, I; Nakayama, S; Sintim, HO  
  选自 期刊  Bioorganic & Medicinal Chemistry Letters;  卷期  2012年22-2;  页码  881-885  
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[摘要]C-di-GMP has emerged as an important bacterial signaling molecule that is involved in biofilm formation. Small molecules that can form biologically inactive complexes with c-di-GMP have the potential to be used as anti-biofilm agents. Herein, we report that water-soluble diamidinium/iminium aromatics (such as berenil), which are traditionally considered as minor groove binders of nucleic acids, are capable of aggregating c-di-GMP into G-quadruplexes via pi-stacking interactions. (C) 2011 Elsevier Ltd. All rights reserved.

 
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