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Substituted azaquinazolinones as modulators of GHSr-1a for the treatment of type II diabetes and obesity

作者	Hanrahan, P; Bell, J; Bottomley, G; Bradley, S; Clarke, P; Curtis, E; Davis, S; Dawson, G; Horswill, J; Keily, J; Moore, G; Rasamison, C; Bloxham, J

选自	期刊 Bioorganic & Medicinal Chemistry Letters; 卷期 2012年22-6; 页码 2271-2278

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[摘要]：Substituted azaquinazolinones were identified as antagonists of the GHSr-1A receptor for the treatment of type II diabetes and obesity. Optimisation for potency and LogD lead to the identification of orally bioavailable, potent antagonists with improved selectivity over hERG. (C) 2012 Elsevier Ltd. All rights reserved.
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