[摘要]：The opioid system regulates food choice, consumption, and reinforcement processes, especially for palatable meals such as fatty food. beta-Endorphin is known as an endogenous opioid peptide produced in neurons of the hypothalamus. In this study, we found that Intralipid (fat emulsion) ingestion increased c-fos expression in beta-endorphin neurons. However, intragastric infusion of Intralipid only slightly increased c-fos expression 2 h after infusion. Further, dissection of glossopharyngeal nerve, innervating posterior tongue taste buds, partially but significantly decreased the Intralipid-induced c-fos expression. These results indicate that mainly the orosensory stimulation from fat may activate beta-endorphin neurons, thereby promoting beta-endorphin release. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
