Synthesis of the Selective Neuronal Nitric Oxide Synthase (nNOS) Inhibitor 5,6-Dibromo-2 '-demethylaplysinopsin

[摘要]：The first synthesis of the selective neuronal nitric oxide synthase (nNOS) inhibitor 5,6-dibromo-2'-demethylaplysinopsin is described. The rare 5,6-dibromoindole moiety was constructed using a previously unused dibromination of an indole-3-carboxylate, the product of which was verified by X-ray crystallography. It was discovered the natural product was characterised as its trifluoroacetate salt in the isolation report.

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