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[摘要]：An in situ generated catalyst from readily available RuH2(PPh3)(4), an N-heterocyclic carbene (NHC) precursor, NaH, and acetonitrile was developed. The catalyst showed high activity for the amide synthesis directly from either alcohols or aldehydes with amines. When a mixture of an alcohol and an aldehyde was reacted with an amine, both of the corresponding amides were obtained with good yields. Homogeneous Ru(0) complexes such as eta(4)-1,5-cyclooctadiene)(eta(6)-1,3,5-cyclooetatriene)-ruthenium [Ru(cod)(cot)] and Ru-3(CO)(12) were also active in the amidation of an alcohol or an aldehyde with the help of an in situ generated NHC ligand. |
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