Vein Patterning 1-encoded progesterone 5 beta-reductase: Activity-guided improvement of catalytic efficiency

[摘要]：Progesterone 5 beta-reductases (P5 beta R; EC 1.3.99.6) encoded by Vein Patterning 1 (VEP1) genes are capable of reducing the C=C double-bond of a variety of enones enantioselectively. Sequence and activity data of orthologous P5 beta Rs were used to defi

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