Discovery of a new binding mode for a series of liver X receptor agonists

[摘要]：Structural modification of a series of dual LXR alpha/beta agonists led to the identification of a new class of LXR beta partial agonists. An X-ray co-crystal structure shows that a representative member of this series, pyrrole 5, binds to LXR beta with a reversed orientation compared to 1. (C) 2012 Elsevier Ltd. All rights reserved.

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