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[摘要]:A facile synthesis of bis-beta-lactams has been executed using chloromethylenedimethylammonium chloride (Vilsmeier reagent), prepared easily from N,N-dimethylformamide and phosphorus oxychloride. It works out as a versatile acid activator reagent for the direct [2 + 2] ketene-imine cycloaddition of substituted acetic acid and bis-imines in one-pot synthesis under mild conditions. Thus, this method has been proved as a high yielding, efficient, and cheap protocol for bis-beta-lactam synthesis. |
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