| |
[摘要]：The asymmetric organocatalyzed alpha-alkylation of aldehydes via a cationic radical enamine intermediate was performed under environmentally benign electro-oxidation conditions without the use of chemical oxidants To promote the desired a-alkylation reaction of aldehydes, various aldehydes with xanthene or cycloheptatriene groups were exposed to electro-organocatalytic conditions to afford optically active usubstituted aldehydes (alpha-alkylated aldehydes) in good yield A reaction mechanism involving the cationic radical enamine was proposed based on the cyclic voltammetry (CV) results, DFT calculations, and control experiments. |
|
