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Chlorin-PEI-labeled cellulose nanocrystals: Synthesis, characterization and potential application in PDT

  作者 Drogat, N; Granet, R; Le Morvan, C; Begaud-Grimaud, G; Krausz, P; Sol, V  
  选自 期刊  Bioorganic & Medicinal Chemistry Letters;  卷期  2012年22-11;  页码  3648-3652  
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[摘要]This Letter reports the synthesis and characterization of a new series of water-stable and soluble photosensitizers (PS-CNCs) composed of cellulose nanocrystals (CNCs) bearing polyaminated chlorin p6. With a view to improve cancer cell targeting, these photosensitizers were assayed for their antitumor activity against HaCat cell line. IC50 values fell within the nanomolar-range, making these photosensitizers promising for further in vitro and in vivo investigations. (C) 2012 Elsevier Ltd. All rights reserved.

 
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