Synthesis and evaluation of isomers of melleumin B from the myxomycete Physarum melleum; an approach for WNT signal inhibitor trusted in nature.

[摘要]：Two stereoisomers of melleumin B, seco acid Me ester of melleumin A, which are novel peptide compds. isolated from the myxomycete Physarum melleum, were synthesized and evaluated for their inhibition of Wnt signal transcription. The 3R-epimer and (3R,4S,10R,11R)-isomer of melleumin B showed moderate inhibition of the Wnt signal.

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