A simple desymmetrization approach to the spiroxin framework.

[摘要]：The highly strained hexacyclic framework I of spiroxins, a family of 1,8-dihydroxynaphthalene-derived natural products, was efficiently constructed in 10 steps from com. available naphthalene-1,5-diol using a symmetry-based strategy. Key reactions in this synthesis are biaryl homocoupling, oxidative desymmetrization of a C2-sym. intermediate, selective oxidn. of the naphthalene portion, and oxidative cyclization.

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