Catalytic Asymmetric Synthesis of (+)-Anthecotulide Using Enyne and Meyer-Schuster Rearrangements

[摘要]：The bioactive sesquiterpene lactone (+)-anthecularin (1) is synthesized for the first time, in a six-step sequence devoid of protecting groups. The key transformations are a novel Rh(I)-catalyzed asymmetric enyne rearrangement of a terminal alkynyl ester (4), to form the alpha-methylene-gamma-butyrolactone core, and a final-step mild Au(I)-catalyzed Meyer-Schuster rearrangement

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