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Synthesis of a Benzomacrolactone-Based Somatostatin Mimetic

  作者 ZHOU JIAN; MATOS MARIECHRISTINE; MURPHY PAUL V  
  选自 期刊  Organic Letters;  卷期  2011年13-21;  页码  5716-5719  
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[摘要]The benzomacrolactone is a framework found in numerous natural products. The synthesis of an orthogonally functionalized benzomacrolactone from D-glucosamine and a salicylic acid derivative is described. This macrolactone was used for the synthesis of a somatostatin mimetic that has submicromolar affinity for the human somatostatin receptor 4 (hSSTR4).

 
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