Synthesis of Tubuphenylalanines via Ireland-Claisen Rearrangement

[摘要]：The Ireland-Claisen rearrangement is the central step in the synthesis of tubuphenylalanine, a key building block of the highly antitumor-active tubulysins. The rearrangement of substituted beta-amino acid ally! esters, in combination with subsequent decarboxylation and oxidative cleavage of the double bond, allows the highly stereoselective introduction of substituents into the alpha-position of the resulting gamma-amino acids.

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