New Highly Efficient Stereoselective Synthesis of D-threo-PDMP

[摘要]：Starting from a suitably functionalized aziridine, a highly efficient stereoselective synthesis of (1R,2R)-phenyl-2-decanoylamino- 3-morpholinopropan-1-ol (D-threo-PDMP) is described. The approach, based on the ring expansion of the aziridine ring to oxazoline, could be applicable to the synthesis of many analogues with different amide chains and sugar mimic portions.

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