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Synthesis of beta-Aminocyclohexanones and beta-Aminocyclohexanols through an Intramolecular Tandem Isomerization-Mannich Reaction as a Key Step

  作者 HAI THUONG CAO; GREE DANIELLE; GREE RENE  
  选自 期刊  Synthesis;  卷期  2011年-20;  页码  3297-3300  
  关联知识点  
 

[摘要]New beta-aminocyclohexanones and beta-aminocyclohexanols, with a primary amino group, have been obtained by a short and efficient sequence involving an intramolecular tandem isomerization- Mannich reaction as the key step. This methodology takes advantage of tert-butanesulfinyl protection of the nitrogen atom.

 
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