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[摘要]:Treatment of N-substituted formamides with chlorophosphate compounds such as PhOPOCl(2), EtOPOCl(2), Me(2)NPOCl(2), and (PhO)(2)POCl and tertiary amines such as triethylamine, pyridine, and N,N-diisopropylethylamine produced the corresponding isocyanides in high yields. This method can be used to prepare various alkyl and aryl isocyanides. |
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