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[摘要]：A simple, mild, and efficient one-pot, three-component synthetic method has been developed for the preparation of alpha-aminophosphonates using phenylboronic acid as catalyst under solventfree conditions at 50 degrees C. The process involves the reaction of carbonyl compounds (aldehydes or ketones) with benzylamine and dimethyl phosphite. A wide range of carbonyl compounds are compatible with this reaction, producing tertiary and quaternary alpha-aminophosphonates in moderated to excellent yields in short time. |
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