Total Synthesis of (+/-)-Dragmacidin E; Problems Solved and Lessons Learned

[摘要]：(+/-)-Dragmacidin E was synthesized in 25 steps from commercially available 7-(benzyloxy) indole. Key transformations in the preparation of this sponge metabolite include (a) a Witkop cyclization to establish the bridging indole core, (b) cyclo-dehydrative pyrazinone formation to unite the two indole-bearing components, and (c) late-stage guanidine installation through chemoselective carbonyl activation. 1 Introduction 2 Results and Discussion 2.1 Model System Synthesis 2.2 (+/-)-Dragmacidin E Synthesis 3 Conclusions

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