Regioselective Tandem Ring Closing/Cross Metathesis of 1,5-Hexadien-3-ol Derivatives: Application to the Total Synthesis of Rugulactone

[摘要]：A tandem ring-closing metathesis/cross-metathesis procedure was devised for the synthesis of various pyrones. The reaction occurred with high regioselectivity and E stereocontrol of the lateral unsaturated chain. This process was applied to the synthesis of rugulactone, an inhibitor of the nuclear factor NF-kappa B according to a four-step sequence.

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