Modular Asymmetric Synthesis of P-Chirogenic b-Amino Phosphine Boranes.

[摘要]：A short concise route to b-aminophosphine boranes is presented via the desymmetrization of prochiral phosphine boranes, forming P-chirogenic aldehydes that are rapidly transformed to the target compds. employing reductive amination under microwave irradn. This sequence provides a modular route to P-chirogenic P,N ligands, and in addn., the intermediate aldehydes are versatile P-chiral building blocks for ligand design in general. An alternative pathway via the corresponding a-carboxyphosphines is also described. The ligands were subsequently evaluated in the asym. conjugate addn. of diethylzinc to trans-b-nitrostyrene.

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