DESIGN AND SYNTHESIS OF A CONFORMATIONALLY RESTRICTED ANALOGUE OF THE EFGH-RING SYSTEM OF CIGUATOXIN

[摘要]：The fused-hexahydrooxonine (F-ring) of ciguatoxin (CTX), as well as its EFGH-ring fragment, undergoes a slow conformational change between two conformers in solution. In this paper, we designed and synthesized a conformationally restricted analogue of the EFGH-ring system of ciguatoxin. Chemo- and stereoselective epoxidation of the F-ring successfully impeded the dynamic behavior without affecting the overall three-dimensional shape of the molecule.

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