Photochemical Generation and Reactivity of the Major Hydroxyl Radical Adduct of Thymidine

[摘要]：5,6-Dihydro-5-hydroxythymidin-6-yl radical (1), the major reactive intermediate resulting from hydroxyl radical addition to C5 of the pyrimidine, is produced via 350 nm photolysis of a 2,5-dimethoxyphenylsulfide precursor (2). Competition between O-2 and thiol for 1 suggests that the radical reacts relatively slowly with beta-mercaptoethanol compared to other alkyl radicals. Overall, aryl sulfide 2 should be an effective precursor for the major hydroxyl radical adduct of thymidine in DNA.

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