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A Facile and Green Synthesis of a Naphthyridine Derivative: A Novel Hedgehog Pathway Modulator

  作者 SHIEH WENCHUNG; XUE SONG; MCKENNA JOE; PRASAD KAPA; PRASHAD MAHAVIR  
  选自 期刊  Synthesis;  卷期  2010年-20;  页码  3429-3432  
  关联知识点  
 

[摘要]A green and highly efficient synthesis of a naphthyridine derivative, a novel hedgehog pathway modulator, in high yield and purity from inexpensive starting materials is described. The key step involves an acid-promoted aryl amination reaction of aniline with naphthyridine halides.

 
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