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Titanium-Catalyzed Cyclopropanation of Boc-Protected Cyanohydrins: A Short Access to Aminocyclopropanecarboxylic Acid Derivatives

  作者 PEARSONLONG MORWENNA S M; BEAUSEIGNEUR ALICE; KAROYAN PHILIPPE; SZYMONIAK JAN; BERTUS PHILIPPE  
  选自 期刊  Synthesis;  卷期  2010年-20;  页码  3410-3414  
  关联知识点  
 

[摘要]The preparation of protected 1-aminocyclopropanecarboxylic acid was performed from readily available and inexpensive starting materials, using titanium-catalyzed cyclopropanation as the key step. As an extension of this methodology, a diastereoselective synthesis of the cis-2-vinyl-substituted analogue is presented.

 
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